Tuesday, January 13, 2009

Easy to be confused with lung diseases signal

Easy to be confused with lung diseases are tuberculosis, pneumonia, lung abscess, lung benign tumor Mucormycosis
(1) Tuberculosis: diagnosis of lung cancer and tuberculosis most confused. Tuberculoma, hilar lymph node tuberculosis, acute miliary tuberculosis, hollow shape, such as pleural effusion TB change, can be very similar to lung cancer.
Tuberculoma was particularly prevalent in young patients with TB lesions at a good site (apex, the leaves and under the dorsal posterior segment), the border clear, and sometimes contains calcifications, often around the satellite kitchen. If so empty formation, while as the center empty, thin wall, rules, can be found in sputum Mycobacterium tuberculosis. These features and peripheral lung cancer can be differential.
Hilar lymph node tuberculosis and central lung cancer easily confused, but the former were more common in children or young people, many TB poisoning symptoms such as fever, tuberculin test positive, effective anti-TB treatment.
Acute miliary tuberculosis with diffuse alveolar carcinoma phase identification. The former patients younger fever and other symptoms of systemic poisoning, X-ray on the see-distributed, small, light density of miliary nodules on both sides of symmetry, often accompanied by toxaemia. And diffuse alveolar carcinoma size两肺see Disseminated nodular lesions, border clearance, the density of the deep, progressive development of the expansion of clinical sexual difficulty breathing.
Tuberculous pleural effusion by pleural effusion out mostly yellow, hydrothorax can identify Mycobacterium tuberculosis, and malignant pleural effusion is mostly blood, which can be found in cancer cells.
(2) pneumonia: cancer should be to identify obstructive pneumonia. Sharp onset of pneumonia, there shivering, fever and other symptoms毒血, and then respiratory symptoms, antibiotic therapy effective, rapid absorption of lesions, rare hemoptysis, and obstructive pneumonia cancer inflammatory infiltration slow absorption, absorption is not complete, often hemoptysis. But the most reliable methods of identification for sputum cytology examination or bronchoscopy.
(3) pulmonary abscess: with cancer empty secondary infection phase identification. Primary pulmonary abscess acute onset, poisoning symptoms, often high fever, chills, cough, sputum pyronaridine stinking lot of pus, blood cells and neutrophils increased. See the X-ray thin hollow wall with a fluid level, surrounded by inflammatory changes. The first empty cancerous lung cancer symptoms such as chronic cough, sputum blood repeatedly, and then cough aggravated脓痰number. See chest cancer are eccentric empty mass, wall thickness, wall surfaces. Sputum cytology and bronchoscopy can be further identification.
(4) benign lung: is characterized by fewer symptoms, course length, X-ray on the brink of mass see smooth, rare sub-leaf density, calcifications were petal-like structure. Such as chondroma, hamartoma, such as benign lipoma. If growth in the bronchial lumen can have obvious symptoms, but a longer course of disease and lung cancer different.
(5) pulmonary aspergillosis: in the chest was often accompanied by mass around the sub-stoves, there were often empty formation of a single small-form-like; a diffuse disease often showed a small mass and distribution of asymmetry on both sides. Sputum culture-shaped bacteria often Minowa or Candida albicans.  lung metastasis What are the symptoms
Malignant lung is the highest organ fat, according to statistics about 50% of malignant tumors spread through direct infiltration, airway cultivation, lymphatic metastasis and blood to the lungs, cough, hemoptysis or血痰, chest pain, if the tumor metastasis to the bronchial has been the subject of obstructive pneumonia and atelectasis, fever, chest tightness, dyspnea and other symptoms.

Treatment of pleural effusion of lung cancer drug

Pleural effusion caused by lung cancer chemotherapy in the diagnosis of lung cancer when combined 1 percent of patients have a pleural effusion, has been no surgical indications. At this point, only to receive chemotherapy temporary effect. Commonly used drugs are as follows:

1, nitrogen mustard

Asepsis will be in the chest cavity effusion pumping as much as possible to do (also placed small ducts), according to 0.4mg/kg, diluted with saline 200m1, one into the chest, once the largest amount of not more than 20mg. Immediately after injection to allow patients to change the direction of position, continuing for about 15 minutes to ensure even distribution of all liquid surface of the chest cavity. Once a week. Effective rate was 55% ~ 87%, a week before and after the drug should pay attention to the situation of bone marrow function and whole body.

2. Ah Ping

Its response rate of about 64% ~ 88%, the drug will enable the emergence of inflammatory pleural adhesion, gap disappeared. The beginning of the available 50 ~ 100mg dissolved in saline injection in lomi chest, if the patient's response is not heavy, every 2 ~ 5, the further injection of 100 ~ 200mg, until the liquid until reduced. Can also be used 600 ~ 800mg single injection. The main reaction to fever, local pain, there are some low blood pressure patients.

3. Tetracyclines

Tetracycline as a hardening agent for cancer treatment of pleural effusion. Are generally placed in a sealed chest catheter to the tetracycline 500mg dissolved in 30ml normal saline into the thoracic cavity, and then injected saline 10m1 washing pipe, duct clamp 6 hours and at the same time continue to transform the body, and then suction drainage tube then about 24 hours to determine the non-liquid and then pull out the drainage tube. It is reported that patients on other drugs (nitrogen mustard, etc.) is invalid, the method succeeded in controlling the growth of liquid 3 ~ 19 months. Satoshi Kitamura also reported the use of doxycycline 500mg, 2 weeks Intrapleural injection 2 or 3 times, the liquid can completely disappear.

4. Other

Self-ADM of adenocarcinoma-induced pleural effusion is better, the chest cavity of a 6 ~ 12mg. In addition, canola can also be used Xiaoliu 30 ~ 40mg / meeting, 5 - fluorouracil 750 ~ 1000mg / times. There are colloidal gold (198Au) colloidal phosphate (32P) and the polio vaccine, Ⅱ, Ⅲ type vaccinia vaccine.

Research progress of lung cancer chemotherapy

Times of life "to fight cancer to enjoy life," the Forum a series of reports

Chemotherapy is one of the means of treatment of lung cancer, especially in the past 10 years, chemotherapy drugs and treatment programs to enhance the development of non-small cell lung cancer after chemotherapy efficacy, reduced toxicity.

In 1995, the British medical journal published by the international non-small cell lung cancer collaborative group of 52 global research summary, when the results of the view that non-small cell lung cancer adjuvant chemotherapy after surgery or not, patients with metastasis and recurrence rate and no difference in survival time .

Therefore, at the time to surgical resection of non-small cell lung cancer, are not in favor of chemotherapy after surgery.

Subsequent years, many new, more effective chemotherapy drugs are all listed, the more clinical trials are under way.

In 2003, the international adjuvant chemotherapy for lung cancer in the United States Conference of Clinical Oncology (ASCO) meeting on the report of 1867 cases of non-small cell lung cancer research findings: post-operative use of platinum drugs in patients with adjuvant chemotherapy and no chemotherapy, compared to patients , 5-year survival rates were 44% and 40%, which can prove that chemotherapy can improve the efficacy, but 23 percent of patients have a more obvious toxicity.

By 2004, the National Cancer Institute of Canada study, 482 cases of Ⅰ B and Ⅱ non-small cell lung cancer patients, vinorelbine plus cisplatin chemotherapy and non-chemotherapy compared to 5-year survival rates were 69% and 54 %, chemotherapy group of 5-year survival rate increased by 15%. That same year, the United States reported in 344 cases of patients, post-operative use of carboplatin in the treatment of Catalonia, the 4-year survival rate was 71 percent, than non-chemotherapy increased 12%.

Now, non-small cell lung cancer has begun to take shape a consensus, usually加泰索Dili cisplatin, paclitaxel, gemcitabine, vinorelbine, etc. A. According to patient's specific circumstances, to choose different combinations can be achieved to improve efficacy, reduce toxicity purpose, especially targeting drug emerged, its mechanism and different from traditional chemotherapy drugs. Traditional chemotherapy drugs are cytotoxic drugs, is toxic to kill tumor cells, but at the same time will inevitably harm normal cells. The targeted drugs into tumor cells can block the adoption of specific epidermal growth factor receptor pathway, inhibit tumor cell proliferation, invasion, metastasis, adverse reactions of light, the patient can be well tolerated.

The country into at least two patients with lung cancer are being "over-treatment“

Lung cancer death rate over the past decade has become the fastest-growing tumor diseases, into at least two patients are receiving "over-treatment." "Over-treatment" not only fail to achieve better therapeutic effect, but increased the suffering of patients. "Over-treatment" mainly refers to surgery and radiotherapy abuse. Surgical patients with lung cancer is the main method of treatment. Statistics show that the method of examination as a result of the slow and anti-cancer awareness is not strong, was diagnosed with lung cancer, the 75% of patients have locally advanced or advanced in lost opportunities for surgical treatment. However, the clinical physicians or patients still insist on surgical treatment, he met four diagnosed with lung cancer (late) after the surgery patients. In addition, patients with early stage lung cancer after surgical resection of lesions, no radiation, there are still some patients to receive radiotherapy for insurance purposes, they undermine the body's immune system.

According to Wei Ge, the lung cancer death rate is the fastest over the past decade tumor, the average mortality rate has reached 116/10 million, more than 10 years ago, more than doubled. Smoking, air pollution and inhaled fumes kitchen is an increase in lung cancer patients an important reason.

Individualized treatment of lung cancer

The beginning of the year, a 55-year-old male patient with chest pain due to血痰, CT examination revealed left lower lung shadow was diagnosed as lung cancer in a hospital in the lower left pneumonectomy and mediastinal lymph node dissection and postoperative pathologic diagnosis was no lymph node metastasis in early lung adenocarcinoma. Unfortunately, this should be the extremely lucky, because the early effects of surgical treatment of lung cancer has been quite good. However, whether postoperative adjuvant therapy should be carried out to produce a heated debate. Party's view is: Although patients with early lung cancer, but the pathological type is adenocarcinoma, there are easy to transfer the tendency for insurance purposes, should be held in post-operative chemotherapy and radiotherapy to prevent recurrence and metastasis. The other view is that: Since the early days, so do not overdo plus chemotherapy and radiotherapy, not to mention the two treatments are not 100 percent effective. Two points of view refused to give joy to win, but also suffered the patients, how to choose?

Medical activities is uncertain and full of controversy and, for the best cancer treatment, almost no unanimous view, more often is the public that the public and reasonable, rational po po said.

First take a look at this case the need for postoperative radiotherapy. The 20th century, 90 years ago, many doctors for insurance purposes, often to allow lung cancer patients - whether early or late relative ---- accepted after mediastinal radiotherapy, and its purpose is to reduce local recurrence and metastasis to extend the life of patients The survival time. Unfortunately, this goal can not achieve. Through an integrated high-quality clinical research findings, we were astonished to find, for early lung cancer, using the old methods of postoperative radiotherapy, not only fail to improve survival rates, but increased mortality. The cause of death was mainly caused by radiation therapy-induced complications. Therefore, in lung cancer has been made in academic circles for such a consensus for early lung cancer, there is no need to give the old methods of postoperative radiotherapy. Of course, the premise is that these early stage lung cancer, including the same side of the mediastinal lymph nodes must be removed clean.

Well, then chemotherapy?

The so-called chemotherapy, is the adoption of several anti-cancer drugs combined into a certain program for cancer patients. As a result of intravenous drug delivery is, therefore, the drug's role is systemic, a feature that allows doctors often consider the use of chemotherapy to eliminate or prevent the transfer of specific cancer cells. However, until now, a large number of clinical research tells us that post-operative chemotherapy for early lung cancer patients would have minimal benefits, we look forward to the chemotherapy drugs significantly reduce or even eliminate the cancer cells the effect of transfer did not occur. But the chemotherapy drugs to patients has brought about obvious side effects: hair loss, vicious vomiting, leukopenia and so on. Therefore, we must in the early post-operative chemotherapy in lung cancer to choose between the pros and cons. On the current evidence available, under normal circumstances do not advocate for such patients postoperative chemotherapy.

But things is not absolute. Since the early lung cancer, in general, there was a slight benefit of postoperative chemotherapy, then the possibility of a slight overall advantage of these transformed into the absolute benefits of a particular patient? If so, how to choose the patients? How reasonable the application of anti-cancer drugs? Here, it gives us of early lung cancer patients should also be divided into two serious proposition.

In 2001, we launched a research project, that is the nature of lung cancer through research, of lung cancer by detecting changes in a number of tags to see if it early screening of lung cancer metastasis and recurrence in easy, but it is also sensitive to chemotherapeutic drugs in particular type, we call the early lung cancer in high-risk type, this type of lung cancer patients given postoperative chemotherapy, it may be targeted rather than feeling the way across the river. Day-ping to the benefit of chemotherapy in the direction of tilt, we should not hesitate to adjuvant chemotherapy patients. When we can not identify early lung cancer in high-risk type, the early post-operative chemotherapy in lung cancer patients are naturally cautious.

The tremendous progress of medical science, allow us to early lung cancer after treatment with some of the new attempt. A step forward in this regard, just the most important new drugs in foreign markets, "the Iraqi force Sand" (Iressa). Mechanism of this drug is completely different from previous chemotherapy, it will not bring to patients, such as hair loss and bone marrow transplant side effects, because it is the role of signal transduction in cells of a certain point, it is called targeted therapy. In Japan and Europe and the United States study, the Iraqi forces were on the sand refractory lung cancer can be achieved satisfactory results. Application of the former period of time, our experience also shows that the Iraqi forces sand on a small tumor burden of patients particularly effective. Therefore, in foreign countries have begun to force the Iraqi sand as postoperative adjuvant treatment of early lung cancer drugs, clinical research, believe that in the near future, we will be able to find early lung cancer one of the most appropriate model of comprehensive treatment.

The beginning of this article that patients who have not received postoperative chemotherapy or radiotherapy. Almost one year since, the patient did not show any tumor recurrence or metastasis of the signs, which initially proved correct treatment measures. Of course, the final conclusion, to be observed in recent years.

In response to the title of this article, lung cancer treatment, is not an easy task, which requires a doctor's knowledge, wisdom, courage, technology, ethics and conscience, but also of lung cancer patients and their families and with the knowledge of doctors with . What is the treatment of lung cancer better able to speak a few words is not clear, but its basic elements, that is, according to phases and physical state of the first to develop the basic principle of treatment, and then in this framework can be the basis of all patients Comprehensive after specific information to determine the details of the design of treatment, which is the highest state of lung cancer ---- individual treatment.

Chinese medicine non-toxic lung cancer adjuvant therapy

Lung cancer is the Oncology bronchial diseases, early treatment of choice for surgical resection. However, due to various reasons, medical treatment, most patients have advanced to lost opportunities for surgical treatment. In recent years, Chinese medicine treatment of lung cancer has been cause for concern efficacy in alleviating symptoms and prolong survival time has played a feature. The traditional Chinese medicine for lung cancer Etiology, Pathogenesis, Diagnosis and Treatment of the relevant literature and clinical experience are summarized below.

1 sputum knot is the pathological basis of lung cancer

"Nan-Jing" goes: "lung of the product, fine-sounding name Ben income ... ... It is cold and heat sprinkling rate, cough, pulmonary obstruct." "Qi Suwen disease theory" goes: "胁下full gas against the disease, two or three very fine-sounding name ... ... disease rate plot." "Yu-machine Suwen Shinzo articles on" documented the advanced lung cancer fever, chest pain Shoulder cited, the symptoms of cachexia, pointing out that "big bone haggard, big meat subsidence, the gas chest full, breathing the inconvenience, which cited shoulder pain , the body heat from the meat breaking  ". Can be seen, "Ben income", "obstruct the lung", "interest rate plot," "pulmonary plot" are traditional Chinese medicine can be classified as bronchial lung disease areas.

Pathogenesis of lung cancer, "Origin and Development of rhinoceros and Miscellaneous Diseases candle" on a more fair, said: "evil plot chest, blocking inverse gas, gas may not pass for sputum ... ... for the blood, are邪正相搏, evil not only win, are not allowed on the system was formed and shaped block. " The awareness of colorectal sputum chest tangible result of the pathogenesis caking. And whether it is within the virtual righteousness, organs disorders, or transgression外邪lungs, cold and heat too, have to undergo a lung Ben Yu, the accumulation of phlegm into the pathological process. Without sputum, there is no plot to Health and lung, the sputum colorectal cancer in the lung is the pathological basis.生痰spleen for the source of the lung for the storage of sputum, and lung Qi Deficiency, yin and yang, estranged by the cold or wind-heat in the evil, the beginning not to accumulate virtual祛邪are ineffective, so time reveals detention into phlegm, sputum gas cementation is a plot into the lung. Phlegm of heat, burn the blood, then spit sputum cough blood. Subcutaneous痰凝forward to, then see缺盆tuberculosis, flow in the bone, then into Gubi, flow in the brain, the目瞑headache. Visceral Disease lung machine with the lungs, spleen two closely related to the dirty, sputum colorectal cancer through the original sent to the transfer of the entire course.

2 Syndrome Treatment

According to the pathogenesis of lung cancer, according to TCM Syndrome Differentiation characteristics, generally divided into the lung to lung cancer Yu-heat, Qi-deficiency and dampness, heat deficiency, Yin Deficiency four common clinical syndrome types. Its main points of differentiation and treatment methods are as follows.

2.1 Yu-heat type of lung disease

Cough poor, bloody sputum, chest pain or shortness of breath胸胁, lips dry mouth, constipation, red tongue or暗红, moss yellow, pulse string or thin string. The evidence for lung Ben Yu,痰壅blood stasis. Xuanfei治宜qi, removing除痰. Side with the daughter of Weijing Decoction. Prescription: Weijing 30g, peach kernel, Health coixenolide, poria, white gourd-jen of the 15g, Zhejiang Fritillaria 20g, mulberry leaves, Notoginseng the 10g, Sauropus 5g, law Banxia 12g, dried tangerine peel, licorice all 6g.

Qi-deficiency syndrome phlegm Type 2.2

痰多coughing, chest tightness, short-gas, gas lazy words纳呆weight loss, abdominal distension would pond. Dark or light red tongue short while toothed India and Carex白腻pulse moisten or Waterloo. Evidence is weak lung, cervical disease and the mother of missing spleen Jian Wan, dampness resistance.治宜Buqi Jianpi,除痰Sanjie. Side with Shenling Baishu Powder. Prescription: Changium, Health coixenolide the 20g, Poria, Atractylodes macrocephala, Zhejiang Fritillaria, white lentils, fried pangolin (先煎) of 15g, Chinese yam 25g, Campanulaceae, villosum (after) the 10g, dried tangerine peel, licorice all 6g .

2.3 Deficiency-heat-type disease

Cough less sputum, or dry cough, throat irritation, or expectoration with bloodshot, chest full of breath, hot flashes sweating, dizziness, ringing in the ears, upset dry mouth, yellow urine, dry stool. Red purple-red tongue, moss-ray stripping or no moss tongue-ray pulse can not string a few. The evidence for lung kidney-yin deficiency, heat Phlegm,治宜Zishen Qingfei,除痰Qingre. Side with diarrhea White Powder. Prescription: Morus alba,生地黄, Anemarrhena, Adenophora, Ophiopogon, Zhejiang Fritillaria, turtle (先煎), Health coixenolide, Yuxingcao the 15g, licorice 6g.

Yin Deficiency Syndrome Type 2.4

Dry expectoration less咳声low, or less bloody sputum, weight loss神倦, dry mouth short gas, loss of sleep soundly目瞑, irritability palpitations, poor body纳差, mamillata dry or嫩红, moss or dry white moss, pulse Shen Fine. Permit an肺脾deficiency, yin depletion. Yiqi Yangyin治宜, Fuzheng In addition to the plot. All parties with Shengmaisan Liuweidihuang Decoction. Prescription: Changium, Ophiopogon, Schisandra, poria,熟地黄, dogwood, lily, Zhejiang Fritillaria the 15g, Chinese yam 25g, Campanulaceae 10g, Cordyceps sinensis, Glycyrrhiza the 6g.

Concise treatment of lung cancer

First, small-cell lung cancer

Treatment with combined chemotherapy and radiotherapy-based.


Commonly used first-line combination chemotherapy programs:

(1) EP or EC: etoposide, cisplatin or carboplatin

(2) CAV: cyclophosphamide + doxorubicin + vincristine

(3) CAE: cyclophosphamide + doxorubicin + etoposide

Second-line program


(1) VIP: Etoposide + Ifosfamide + Cisplatin

(2) IME: Ifosfamide + Methotrexate + Etoposide

Chemotherapy can not immediately ease the transfer of parts, especially the brain, epidural and bone metastases, radiotherapy needed.

Second, non-small cell lung cancer

Early stage non-small cell lung cancer (Ⅰ A, Ⅰ B, Ⅱ A, Ⅱ B) treatment, the preferred surgical resection, postoperative adjuvant chemotherapy. Ⅲ A non-small cell lung cancer patients with preoperative induction chemotherapy (neoadjuvant chemotherapy), and postoperative adjuvant chemotherapy. Can not be surgically removed for locally advanced non-small cell lung cancer can be combined with chemotherapy and radiotherapy. Metastatic advanced non-small cell lung cancer treatment: chemotherapy, biological therapy, supportive therapy. EGFR gene protein over-expression of non-small cell lung cancer treated with ZD1839 available, especially for the poor effect of chemotherapy, and do not advocate and chemotherapy combined.

Combined with chemotherapy commonly used programs:

(1) NP: Navelbine + Cisplatin

(2) PP: Paclitaxel + Cisplatin

(3) GP: Gemcitabine + Cisplatin

(4) TP: Taxotere + Cisplatin